

In the third phase, the clinical, physical, and biochemical parameters, described above, are going to be evaluated by a blinded and trained measurer and the volunteers are going to be accompanied for more 24 sessions of their CRP routines, to register the appearance of their signals and symptoms as well. In the second phase, the volunteers are going to realize their normal CRP routines for 6 months. Following this, clinical (cardiorespiratory parameters and autonomic modulation), physical, and biochemical parameters are going to be evaluated by a blinded and trained measurer and the subjects are going to be accompanied during 24 sessions of their CRP routines, to register the appearance of their signals and symptoms. Two independent blinded and trained measurers are going to realize the risk stratification of the volunteers, using the protocols described into the literature review of Silva et al. Initially, all the volunteers are going to have their medical records analyzed, and information about the sample characterization and medical examinations are going to be extracted. This study is going to be divided in 3 phases.

This study was designed to answer these questions: to evaluate the risk stratification protocols efficacy to previse signals and symptoms during the CRP to analyze the correlation between clinical, physical, and biochemical parameters, measured at rest, with the presence of signals/symptoms in CRP participants and to evaluate whether changes in clinical, physical, or biochemical parameters, induced by CRP, will influence the appearance of signals and symptoms during these programs. How are the risk stratification protocols effective to previse signals and symptoms during the CRP? Can clinical, physical, and biochemical parameters be used to previse signals and symptoms during the CRP? If yes, is it possible to establish a cut-off point for these parameters that can better previse the appearance of signals and symptoms in these programs? Are changes in clinical, physical, or biochemical parameters induced by CRP accompanied by changes in the appearance of signals and symptoms during the CRP? Taken together, these data point to some gaps in the literature. However, some of these protocols efficacy to previse serious complications during the CRP did not obtain significative results. It is important to highlight that patients submitted to a CRP generally have their risk stratified through different protocols, which allows the practitioner to identify their level of cardiovascular risk. Furthermore, these parameters can directly influence the intensity of these alterations promoted by the exercise and, consequently, be related with the appearance of signals and symptoms. However, a literature research did not point studies that analyzed whether these parameters could be used as a risk predictor of signals and symptoms during the CRP session. The literature has shown that clinical, physical, and biochemical parameters, such as heart rate variability (HRV), cardiorespiratory parameters, functional capacity (FC), muscle strength (MS), and inflammatory cytokines, have been used as a risk marker of mortality, cardiovascular complications, and adverse events on different population, and that some of these parameters are also correlated with specific responses during the physical exercise. In this context, to investigate factors that could previse the appearance of signals and symptoms during the CRP, would better guide the strategies adopted for its performance. However, during the physical activity practice, a metabolic demand increase happens and promotes changes in the organism, which can facilitate the occurrence of signals and symptoms commonly found in CRP. Therefore, strategies to treat and prevent CVD are fundamental.Ĭardiovascular rehabilitation programs (CRPs) are highlighted as an efficient way to prevent and treat CVD, mainly because of its beneficial effects.

Cardiovascular diseases (CVDs) are considered the main cause of death in the world and their appearance is associated with changes that directly compromise the quality of life.
